second line detection
less than one hour
Pathlock will provide results in less than one hour and with minimal laboratory equipment. It is based on an innovative genetic technology called CRISPR-Cas13, inspired by the bacteria’s defence against viruses. The system is molecular seek-and-destroy machinery for specifically detecting viral RNAs. For Pathlock, it has been engineered CRISPR-Cas13 to recognise the SARS-CoV-2 RNA and generate a signal when it has been cut. An operator mixes the sample with a solution containing the reagents and reads the result on a dipstick or a cartridge similar to those used for pregnancy tests. This requires minimal training. The Pathlock’s accuracy is expected to be as high as or higher than the current RT-PCR golden standard. It will be suitable for second-line detection in field laboratories and mobile clinics, without the need of specialised centres.